Inflammation as we age
As we age, our bodies undergo numerous changes, some of which lead to an increase in inflammation. Understanding the mechanisms behind this increased inflammation is crucial, not just for comprehending the aging process, but also for identifying potential interventions that can significantly improve our health as we grow older. And we all grow older. Every day. The sooner you act and take responsibility of what you eat and how you live, the better your chances are of leading a long, healthy and functional life. So this is information worth paying attention to regardless if you are 20, 30, 40, 50, 60 or 70…or older or anywhere inbetween!
The Rise of “Inflammaging”
The term "inflammaging" describes the low-grade, chronic inflammatory status that typically accompanies aging. This condition is characterized by increased levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α).
These inflammatory markers contribute to the progressive decline in physiological functions and are associated with various age-related diseases, including muscle atrophy, DNA damage, and an increased risk of hypertension, diabetes, atherosclerosis, and even cancer.
Cell Senescence and Immune System Dysregulation
One of the primary drivers of “inflammaging” is cell senescence. As cells age, they often enter a state where they no longer divide but still remain metabolically active. These senescent cells accumulate in tissues, secreting potent inflammatory molecules that lead to tissue dysfunction and further inflammation [2,4]. This process not only contributes to aging but also to the development of age-related diseases by maintaining a chronic state of inflammation.
Additionally, aging impacts the immune system — a phenomenon known as immunosenescence.
Senescent hematopoietic stem cells often differentiate into various types of dysfunctional immune cells. This transformation skews the immune system towards a pro-inflammatory state, exacerbating the challenges of immune system regulation in older adults [5].
Mitochondrial Dysfunction and Inflammation
Mitochondrial dysfunction also plays a significant role in the ageing process. As we age, the mitochondria in our immune cells, such as macrophages, become less efficient in handling calcium. This inefficiency can trigger these cells to release inflammatory factors, contributing further to chronic inflammation.
So what can you do to avoid or at least prolong this process? Well….avoiding sugar is a good start, especially refined or processed sugar and fast released carbohydrates. Unfortunately you can NOT replace sugar with non-caloric artificial sweeteners, which are as bad, or even worse to some extent, then sugar. Curcumin in combination with black pepper is a natural anti-inflammatory supplement that has good impact.
Curcumin’s Role in Managing Age-Related Inflammation
Given these challenges, finding effective ways to manage inflammation is of great importance. This is where curcumin plays a pivotal role. Curcumin is renowned for its potent anti-inflammatory properties. It can modulate the activity of cytokines, enzymes, and other molecules involved in inflammation, effectively disrupting the inflammatory pathways that lead to aging and associated diseases.
Inflammation is a natural part of the aging process, but it doesn't have to define our later years.
Understanding the underlying causes of increased inflammation with age provides valuable insights into how we can better support our bodies.
I would love to hear your thoughts on this and if you like this kind of information!?